Research

Every eukaryote cell has more than one genome: there are variable genes in both the nucleus, and also in mitochondria. Enzymes encoded by mitochondrial and nuclear genomes must work together to coordinate healthy metabolism. This means that independently-segretating variation in the mitochondrial and nuclear genome can easily have exponential effects, with variation in one being either exaggerated or masked by variation in the other.

In my PhD project I am looking to characterise the chemical signatures of these mito-nuclear interactions, and whether they can be used to predict an individual’s response to diet.